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. 2019 Dec 19;48(4):1886–1904. doi: 10.1093/nar/gkz1162

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — FANCM promotes cellular tolerance to dihydromyricetin. (A) U-2 OS cells were transfected with the indicated siRNAs and exposed to increasing concentrations of dihydromyricetin for 2 days. Cell viability was estimated using Cell Titer-Glo assay. Mean viability is representative of experiments preformed in triplicate. Error bars represent ±S.D. Bottom panel: the efficiency of FANCM, FANCD2 or FANCA knockdown was assessed by western blotting. (B) U-2 OS cells were transfected with FANCM siRNA and cell viability was assessed as described in A. Mean viability representative of quadruplicates. Error bars represent ±S.D. (C) Model: The accumulation of Dihydropyrimidines in cancer cells induces DNA replication and transcriptional stress via the formation of DPCs.