Figure 2.

Somatic spectrum of mutations grouped by cell line and treatment by UVA. Somatic spectrum of all point mutations and its trinucleotide context extracted in each cell line group: (A) XP-V comp, (B) XP-V comp UVA, (C) XP-V and (D) XP-V UVA. Trinucleotide contribution was calculated by its frequency. The two most frequent trinucleotides were highlighted in XP-V comp UVA and XP-V groups as trinucleotides mutations in C>A, C>T, T>A and T>C within pyrimidine dimers (Pyr dimers) in the XP-V UVA group.