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. 2020 Jan 20;48(4):e23. doi: 10.1093/nar/gkz1209

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — MOG visualizations of glypican 3 (GPC3) expression pattern in tumor and non-tumor organs. (A) Line chart generated by interactively filtering by study metadata to retain 3184 samples from 5 tumor types and corresponding non-tumor organs, and grouping the chart by organ/tumor type. (B) Box plot summary of data in (A). Generated by interactively splitting box plot according to organ/tumor type. (C) Scatter plot showing co-expression of GPC3 and Lumican (LUM) in liver non-tumor and LIHC samples. In non-tumor liver (red), GPC3 and LUM expression are strongly correlated (Spearman correlation ≤ 0.7). In LIHC samples (black), GPC3 and LUM expression show no association (Spearman correlation = −0.1). (D and E) Histograms of distribution of Spearman correlation coefficients of expression of GPC3 with all other genes. Non-tumor liver samples (D), LIHC samples (E). The longer right tail of non-tumor liver samples indicates Spearman correlation coefficients of GPC3 expression with selected genes are higher in non-tumor than LIHC samples.