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. 2020 Jan 9;19(3):1824–1830. doi: 10.3892/ol.2020.11271

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Copyright: © Han et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Inhibitory effect of TF on tumor growth in a xenograft tumor mouse model. (A) TF treatment inhibited tumor growth in mice and the tumor inhibition rate of TF was 64.07% compared to PBS group determined the mean tumor volume. (B) TF treatment increased the percentage of apoptotic cells in tumor tissue compared with PBS. (C) Histological analysis revealed that COX-2, Wnt and β-catenin expression levels were significantly decreased in tumor tissues obtained from TF-treated animals compared with the control Magnification, ×100. (D) TF administration significantly increased the survival time over a 100-day period. The Kaplan-Meier method and the log-rank test were used to evaluate the overall survival rate. **P<0.01 vs. PBS. TF, total flavonoids; COX-2, cyclooxygenase 2; TUNEL, terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling.