Figure 4.

miR-202 inhibits cell proliferation and cell glycolysis by targeting HK2 in liver cancer cells. (A) Relative expression of HK2 following Huh7 cell transfection with si-NC or si-HK2. (B) Cell Counting Kit 8 cell proliferation assay was used to evaluate cell proliferation following Huh7 cell transfection with si-NC, si-HK2 or si-HK2 plus miR-202 inhibitor. (C) Relative glucose consumption and (D) lactate production were evaluated following Huh7 cell transfection with si-NC, si-HK2 miR-202 inhibitor or cotransfection with si-HK2 and miR-202 inhibitor. Data are presented as the mean ± SD from three independent experiments. *P<0.05; ^#P>0.05. miR, microRNA; HK2, hexokinase 2; si, small interfering; NC, negative control; inh, inhibitor.