Table 2.

Zero-Order Correlations Among Laboratory and Clinical Measures at Baseline and Their Difference Values (Endpoint – Baseline)

Sodium Benzoate (N=49)	1	2	3	4	5	6	7	8	9	10
1 DAAO baseline	–
2 DAAO difference	−0.255	–
3 SOD baseline	−0.193	0.175	–
4 SOD difference	−0.072	0.080	−0.254	–
5 CAT baseline	0.108	0.280	0.005	0.032	–
6 CAT difference	0.109	−0.167	0.217	−0.268	−0.592***	–
7 BEHAVE-AD baseline	0.297*	−0.062	0.304*	−0.026	0.302*	−0.051	–
8 BEHAVE-AD difference	−0.138	0.001	0.095	−0.321*	−0.294*	0.432**	−0.461**	–
9 ADAS-cog baseline	0.215	0.081	−0.236	−0.006	0.167	−0.034	0.235	−0.239	–
10 ADAS-cog difference	−0.049	0.335*	0.068	−0.127	−0.027	0.185	−0.320*	0.323*	−0.123	–
Placebo (N=48)	1	2	3	4	5	6	7	8	9	10
1 DAAO baseline	–
2 DAAO difference	−0.450*	–
3 SOD baseline	0.057	−0.080	–
4 SOD difference	−0.104	0.192	−0.444**	–
5 CAT baseline	−0.046	0.129	0.053	0.106	–
6 CAT difference	−0.007	0.071	0.079	−0.164	−0.538***	–
7 BEHAVE-AD baseline	0.130	−0.062	0.150	−0.002	0.329*	−0.360*	–
8 BEHAVE-AD difference	−0.224	0.053	−0.232	−0.033	−0.160	0.230	−0.543***	–
9 ADAS-cog baseline	−0.279	0.115	−0.147	0.167	−0.048	−0.044	−0.241	0.194	–
10 ADAS-cog difference	−0.001	−0.143	0.166	0.052	−0.028	−0.146	−0.043	0.346*	−0.007	–

Notes: The zero-order correlations among amino acids levels and clinical measures were insignificant (data not shown). *p < 0.05; **p < 0.01; ***p < 0.001.

Abbreviations: DAAO, D-amino acid oxidase; SOD, superoxide dismutase; CAT, catalase; BEHAVE-AD, Behavioral Pathology in Alzheimer’s Disease Rating Scale; ADAS-cog, Alzheimer’s disease assessment scale-cognitive subscale.