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. 2020 Feb 17;11:46. doi: 10.3389/fendo.2020.00046

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Copyright © 2020 Feng, Xu, Pan, Hu, Wu, Lin, Zhang, Ji, Hu, Zhong, Yan, Zhong and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional enrichment analyses of the mRNAs. (A) The protein-protein interaction (PPI) network was constructed by Search Tool for the Retrieval of Interacting Genes/Proteins. The minimum required interaction score was set as 0.9. (B) The k-score analysis was used to assess the core subnetwork of the PPI network. (C) The hub genes in this subnetwork were associated with two important aging-related pathways, including cell cycle and p53 signaling pathway. (D) GSEA analyses of gene sets for nuclear receptors in lipid metabolism and toxicity, cell cycle, aging, adipogenesis, glycogen metabolic process and ATP synthesis coupled proton transport. NES, normalized enrichment score.