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Pathogenesis for lymphedema. Schematic representing the pathogenesis of lymphedema. VEGF-C, vascular endothelial growth factor C; VEGFR, vascular endothelial growth factor receptor; VE, vascular endothelial; VB, vascular bed; IFV, interstitial fluid volume; IP, interstitial pressure; HP imbalance, the imbalance of hydrostatic pressure difference; E-RVs, existing resistance vessels.
