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Effect of KLG siRNA on subcutaneous tumor. (A) Immunohistochemistry of tumor with KLG and Ki-67 antibodies. (B) Treatment with KLG siRNA led to downregulation of KLG, as expected. (C) In the KLG siRNA and KLG siRNA + DTX treated groups, the proliferation index was lower than in the control and DTX only groups. Mann-Whitney U test was conducted. *P<0.05. KLG, γ-Klotho; siRNA, small interfering RNA; DTX, docetaxel.
