Figure 1.

MARCKSL1 is dysregulated in human lung adenocarcinoma and cell lines. (A) MARCKSL1 mRNA levels were analyzed in six lung adenocarcinoma and normal lung tissue microarray datasets downloaded from the Oncomine database. The results of a representative dataset are presented. (B) KM plots of patients with lung adenocarcinoma with different MARCKSL1 mRNA expression levels (high vs. low) as found in the KM-Plotter database. (C) Representative normal lung and lung adenocarcinoma specimens stained with MARCKSL1. The MARCKSL1 (D) mRNA and (E) protein levels in five lung adenocarcinoma cell lines and a normal lung epithelial cell line were determined by reverse transcription-quantitative PCR and western blotting, respectively. Data are presented as the mean ± standard error of the mean of three independent experiments. ***P<0.001. MARCKSL1, MARCKS like 1; KM, Kaplan-Meier; HR, hazard ratio.