Table I.
Factors regulated by FBW7.
| Author, year | Factors | Function | Reference |
|---|---|---|---|
| Yada et al, 2004 Welcker et al, 2004 | c-Myc | Transcription factor that regulates the expression of many genes | (16,17) |
| Koepp et al, 2001 | Cyclin E | Regulates cell-cycle entry and progression | (18) |
| Weng et al, 2004 | Notch1 | Transcriptional regulators of cell fate and differentiation | (19) |
| Fukushima et al, 2012 | NF-κB | Important factor in many fundamental cellular processes | (20) |
| Wei et al, 2005 | c-Jun | Transcription factor which regulates the cell cycle | (21) |
| Lochab et al, 2013 | G-CSFR | Controls the production, differentiation, and function of granulocytes | (22) |
| Xie et al, 2019 | SHOC2 | Involved autophagy induction and cell survival | (23) |
| Huang et al, 2018 | BRG1 | Involved in governing chromatin structure and gene transcription | (24) |
| Finkin et al, 2008 | Aurora-A | Involved in the cell mitosis and cell cycle regulatory process | (25) |
| Liu N et al, 2010 | KLF5 | Promotes differentiation and self-renewal of fat cells | (26) |
| Kourtis et al, 2015 | HSF1 | Regulates the heat-shock response and supports malignancy | (27) |
| Bengoechea-Alonso et al, 2010 | C/EBPα | Involved in lipid metabolism | (28) |
BRG1, brahma-related gene-1; C/EBPα, CCAAT/enhancer-binding protein α; HSF1, heat shock transcription factor 1; KFL5, Kruppel like factor 5; SHOC2, SHOC2 leucine rich repeat scaffold protein.