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. 2019 Dec 24;219(1):e201910070. doi: 10.1083/jcb.201910070

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© 2019 Buffone and Weaver

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 3. — Tension mediates a glycocalyx-integrin feedback loop in cancer. The glycocalyx drives enhanced mechanical signaling between the integrin–actin axis on the tumor cell and the ECM. This mechanical signaling promotes the up-regulation of genes in the nucleus driving both a more mesenchymal phenotype (production of ECM proteins such as Tenascin C) and a bulkier glycocalyx (such as CD44, hyaluronic acid, and galectin-1) in the tumor. Together, these drive glioma aggressiveness in a tension-dependent feedback loop, which is self-enforcing. Illustration by Neil Smith (http://www.neilsmithillustration.co.uk).