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Contact occupancies for insulin–IR-ECD interactions with a cutoff of 3.5 Å in the MD simulations. (A–D) Contact map showing interactions between IR-ECD and head-bound insulins 1′/1 (A and B) and stalk-bound insulins 2/2′ (C and D). Only contacts with an occupancy >50% are displayed. The arrangement of the maps corresponds to the location of the respective insulin in the ECD (front view; Fig. 2 A).
