Lee 2012

Methods	Parallel RCT
Participants	Country of study: Korea Setting: outpatient clinic Condition: fibromyalgia Prior management details: none reported n = 22 Age mean (SD): low‐frequency group 45.6 (9.6) years, high‐frequency group 53 (4.2) years, sham group 51.3 (6.2) years Duration of symptoms (months mean (SD)): low‐frequency group: 47.2 (20.1), high‐frequency group 57.1 (6.4), sham group 44.7 (10.3) Gender distribution: all F
Interventions	Stimulation type: rTMS Stimulation parameters: Low‐frequency group: frequency 1 Hz; coil orientation not specified, number of trains 2; duration of trains 800 s; ITI 60 s; total number of pulses 1600 High‐frequency group: frequency 10 Hz; coil orientation not specified, number of trains 25; duration of trains 8 s; ITI 10 s; total number of pulses 2000 Stimulation location: right DLPFC (low‐frequency), L M1 (high‐frequency) Number of treatments: 10, x 1 daily (weekdays only) for 2 weeks Control type: sham ‐ coil orientated away from scalp
Outcomes	Primary: 0‐100 mm pain VAS; 0 = none, 100 = an extreme amount of pain When taken: post‐treatment and at 1 month follow‐up Secondary: FIQ
Notes	Comment: no information on AEs given relating to those participants who did not complete all sessions COI: study authors declared no COI Sources of support: no declaration made
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Comment: method of randomisation not specified
Allocation concealment (selection bias)	Unclear risk	Comment: allocation concealment not specified
Adequate blinding of participants?	Unclear risk	Comment: sham credibility assessment ‐ suboptimal. Coil angled away from scalp. Did not control for sensory characteristics of active stimulation and was visually distinguishable
Adequate blinding of assessors?	Unclear risk	Comment: blinding of assessors not specified
Incomplete outcome data (attrition bias) All outcomes	High risk	Comment: no ITT analysis described ‐  appears to be per protocol. 3/8 in low‐frequency group, 2/5 in high‐frequency group and 2/5 in sham group
Selective reporting (reporting bias)	Low risk	Comment: point measures presented in full for all outcomes
Study Size	High risk	Comment: < 50 participants per treatment arm
Study duration	Unclear risk	Comment: ≥ 2 weeks but < 8 weeks' follow‐up
Other bias	Low risk	Comment: no other biases detected