Table 3.
[11C]NOP-1A volume of distribution expressed relative to total plasma concentration (VT) in regions of interest
| Cocaine use disorder | Healthy controls | Uncorrected p-values | |
|---|---|---|---|
| Regions of interest | n = 24 | n = 25 | |
| Amygdala | 16.10 ± 2.48 | 14.86 ± 2.40 | 0.084 |
| Hippocampus | 11.93 ± 1.76 | 10.85 ± 1.53 | 0.027 |
| Midbrain | 9.81 ± 1.40 | 8.72 ± 1.22 | 0.0056 |
| Ventral Striatum | 15.70 ± 2.35 | 13.99 ± 2.21 | 0.0118* |
| Caudate | 12.32 ± 1.99 | 11.56 ± 1.90 | 0.177 |
| Putamen | 14.60 ± 2.18 | 13.37 ± 2.13 | 0.051 |
| Dorsolateral Prefrontal Cortex | 13.97 ± 2.09 | 12.98 ± 2.11 | 0.105 |
| Orbital Frontal Cortex | 14.85 ± 2.40 | 13.68 ± 2.15 | 0.078 |
| Medial Prefrontal Cortex | 13.93 ± 2.14 | 12.96 ± 2.05 | 0.115 |
| Anterior Cingulate Cortex | 14.57 ± 2.18 | 13.39 ± 1.99 | 0.053 |
| Cerebellum | 8.73 ± 1.21 | 7.81 ± 1.03 | 0.0062* |
Values are mean ± SD in cocaine use disorder and healthy control subjects
SD - Standard deviation
*
Significant following multiple hypotheses correction with FDR