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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Pain. 2020 Mar;161(3):619–629. doi: 10.1097/j.pain.0000000000001750

Figure 2. Percent reduction in pain stratified by C allele of ABCB1 rs1045642 and treatment type in the discovery cohort.

Figure 2.

Dots represent individual observations and lines represent fitted values from a linear mixed-effect model. Percent values highlight differences in treatment type efficacy between the homozygotes for the T allele and the homozygotes for the C allele. Under combination therapy, the homozygotes for C allele, on average, reported 88% improvement for pain reduction while the homozygotes for T allele reported 20% improvement for pain reduction. The improvement for pain reduction for C allele homozygotes was 64% in nortriptyline treatment group and 57% morphine treatment group.