(A) The number of total painful body sites reported by subject in the UKBB cohort stratified by treatment group. Dots represent individual observations, bars represent means, error bars represent standard errors. (B) The reduction in number of reported pain sites stratified by C allele of rs1045642 and treatment group. Under combination therapy, the homozygotes for T allele, on average, reported 6 painful sites while the homozygotes for C allele reported 2 painful sites. The number of painful sites did not vary appreciably between the homozygotes for C or T alleles under either monotherapy treatment.