Table 1.

SNPs selected for the genetic association analysis.

Gene or metabolic pathway	rs number	Location	Functional change	Gene symbol	Gene name	Reference
OPRM1 gene	rs1799971	Exon 1	Asn40Asp	OPRM1	Opioid Receptor Mu 1	[4,8–10,24,27,35,44,49]
COMT gene	rs6269	Intron 2		COMT	Catechol-O-Methyl Transferase	[14,43,59,82]
	rs4633	Codon 62
	rs4818	Exon 4
	rs4680	Exon 4	Val158Met
Serotonin receptor	rs6313	Exon 2	T102C	HTR2A	5-Hydroxytryptamine Receptor 2A	[28,45,77,94]
	rs7997012	13:46837850
ABCB1 gene	rs1045642	Exon 26	C3435T	ABCB1	ATP Binding Cassette Subfamily B	[33,36,65]
	rs2032582	Exon 21	Ala893Thr		Member 1
CYP2C19 metabolism	rs12248560	Promoter		CYP2C19	Cytochrome P450 Family 2	[25,30,31,71,80]
	rs4244285	Exon 5			Subfamily C Member 19
	rs4986893	Exon 4
	rs28399504	Exon 1
	rs56337013	Exon 9
	rs72552267	Exon 3
	rs72558186	Intron 5
	rs41291556	Exon 3
CYP2D6 metabolism	rs1065852	22:42130692	P34S	CYP2D6	Cytochrome P450 Family 2	[25,30,31,80]
	rs201377835	22:42129910			Subfamily D Member 6
	rs5030862	22:42130668	G42R
	rs72549357	22:42526657
	rs28371706	22:42129770	T107I
	rs1080985	22:42132375
	rs72549354	22:42128815
	rs59421388	22:42127608	V338M
	rs35742686	22:42128242	259Frameshift
	rs769258	22:42130761
	rs3892097	22:42128945	Splicing defect
	rs28371725	Intron 6	Splicing defect
	rs1135840	22:42126611	S486T
	rs5030655	22:42129084	118Frameshift
	rs5030867	22:42127856	H324P
	rs5030865	22:42129033	G169R
	rs5030656	22:42128174	K281del