Skip to main content
. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Pain. 2020 Mar;161(3):619–629. doi: 10.1097/j.pain.0000000000001750

Table 3.

Association results for SNP rs1045642 and side effects by treatment group in the discovery cohort.

Side effect Morphine Nortriptyline Drug Combination
β (SE) P-value β (SE) P-value β (SE) P-value
Epworth Sleepiness Scale (1-7) 0.07 (0.26) 0.988 −0.08 (0.24) 0.974 −0.11 (0.26) 0.956
Patient Assessment of Constipation Symptoms (0-4) 0.02 (0.19) 0.999 −0.02 (0.19) 0.999 0.07 (0.19) 0.970
Systolic Blood Pressure 3.54 (3.68) 0.657 0.55 (3.58) 0.997 −0.26 (3.67) 0.999
Diastolic Blood Pressure −4.17 (3.27) 0.475 2.68 (3.27) 0.783 −0.49 (3.38) 0.998

The results are based on linear mixed-effect models fitted to the side effects with age, sex, treatment type, SNP, and an interaction between treatment type and SNP. P-values are for contrast coding that evaluate statistical significance of a genetic factor on a side effect under identified treatment group.