Table 5.

Association results for functional SNPs within the ABCB1 gene locus and the number of pain sites by therapy group in the UK Biobank.

ABCB1 SNP	Genotype frequencies			Morphine		Nortriptyline		Drug Combination
	f(AA)	f(Aa)	f(aa)	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value
rs10248420	0.71	0.26	0.03	−0.02(0.05)	0.643	−0.02 (0.04)	0.511	−0.52(0.28)	0.062
rs1045642	0.30	0.48	0.22	−0.02 (0.04)	0.530	0.04 (0.03)	0.138	−0.37 (0.16)	0.022*
rs1128503	0.32	0.49	0.19	0.02 (0.04)	0.595	−0.05 (0.03)	0.061	0.11 (0.17)	0.500
rs11983225	0.77	0.21	0.02	−0.007 (0.06)	0.891	−0.04 (0.04)	0.367	−0.51 (0.32)	0.109
rs12720067	0.77	0.21	0.02	−0.0003 (0.06)	0.995	−0.05 (0.04)	0.258	−0.51 (0.32)	0.109
rs2032583	0.77	0.21	0.02	−0.007 (0.06)	0.891	−0.04 (0.04)	0.367	−0.51 (0.32)	0.109
rs2235040	0.77	0.21	0.02	−0.007 (0.06)	0.891	−0.04 (0.04)	0.406	−0.51 (0.32)	0.109
rs2235067	0.77	0.21	0.02	−0.001 (0.05)	0.983	−0.03 (0.04)	0.431	−0.52 (0.32)	0.105
rs4148739	0.77	0.21	0.02	−0.007 (0.05)	0.891	−0.03 (0.04)	0.367	−0.51 (0.32)	0.109
rs4148740	0.77	0.21	0.02	−0.007 (0.05)	0.894	−0.04 (0.04)	0.320	−0.51(0.31)	0.109
rs7787082	0.71	0.26	0.03	−0.02 (0.05)	0.633	−0.03 (0.04)	0.481	−0.52 (0.28)	0.062

The results are based on a Poisson model fit to the number of pain sites with age, sex, SNP, treatment group, an interaction between SNP and treatment group, and the first 40 principal components as linear predictors.

^*Statistically significant result at α = 0.05 level.