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V(D)J recombination and the structure of human and mouse antibodies. A schematic of the human heavy chain locus is shown, where multiple VH, DH, and JH regions can rearrange in any given B-cell to produce a functional VDJ unit that encodes the heavy chain variable region. A close-up of the antigen binding region (bottom left) illustrates the regions encoded by the V, D, and J gene segments. A full length antibody is shown on the bottom right.
