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. 2020 Feb 24;15(2):e0229260. doi: 10.1371/journal.pone.0229260

Table 2. Clinical findings of all virus-associated anterior uveitis cohorts.

P Value
CMV N = 57 HSV N = 77 VZV N = 45 RV N = 77 MV N = 14 CMV vs HSV CMV vs VZV CMV vs RV CMV vs MV HSV vs VZV HSV vs RV HSV vs MV VZV vs RV VZV vs MV RV vs. MV
Conjunctival redness
29 28 21 21 6 0.0813 0.0929 0.4224 0.0086 0.5907 0.2627 0.3018 0.6441 0.0435 0.8027 0.2867
    no (54) (36) (47) (27) (43)
    yes 28 49 24 55 8
(49) (64) (53) (71) (57)
Corneal edema 0.4614 0.1824 0.4321 0.7663 0.7846 0.6983 0.0958 0.1701 0.2925 0.888 0.9282
54 77 44 72 13
    no (95) (99) (98) (94) (93)
    yes 3 (5) 1 (1) 1 (2) 5 (6) 1 (7)
Keratic precipitate 0.0400 0.2507 0.1627 0.2127 0.2494 0.6902 0.0107 0.6630 0.0072 0.8694 0.035
12 23 15 10 5
    no (21) (30) (33) (13) (36)
    yes 45 (79) 54 (70) 30 (67) 67 (87) 9 (64)
Character of keratic 0.9713 0.52 0.8824 0.8824 0.507 0.8858 0.8858 0.7752 >0.9999 0.6360 0.6360
precipitates 14 41 22 28 9
    not (25) (53) (49) (36) (64)
documented 16 18 10 26 3
(28) (23) (22) (34) (21)
granulomatous 21 (37) 14 (18) 10 (22) 19 (25) 2 (14)
    Fine 6 4 (5) 3 (7) 4 0 (0)
    Pigmented (11) (5)
Location of keratic precipitate 14 (25) 38 (49) 37 (82) 40 (52) 5 (36) 0.6053 0.2713 0.8841 0.8913 0.3416 0.2798 0.2267 0.47459 0.3226 0.3226 0.3072
    not documented 14 (25) 11 (14) 11 (24) 15 (19) 2 (14)
    Arlt´s triangle 25 (44) 28 (36) 29 (64) 22 (29) 7 (50)
    diffuse scattered 2 (4) 0 (0)
    endotheliitis 0 (0) 0 (0) 0 (0)
Cells in anterior chamber 29 (50) 48 (62) 28 (62) 28 (36) 7 (50) 0.5991 0.1846 0.2519 0.2519 0.9531 0.9899 0.9899 0.3852 >0.999 0.4162 0.4162
    no 28 29 17 17 7
    yes (49) (38) (38) (38) (50)
Hypopyon
    no 56 77 43 77 14 0.2434 0.1554 0.4246 0.2434 0.6177 0.0621 0.0621
    yes (98) (100) (95) (100) (100)
1 (2) 0 (0) 2 (4) 0 (0) 0 (0)
Fibrin 0.2145 0.2640 0.5834 0.0898 0.381 0.1263 0.4976 0.8949 0.0435 0.2008 0.8096
    no 53 67 43 64 12
    yes (93) (87) (96) (83) (86)
4 (7) 10 (13) 2 (4) 13 (17) 2 (14)
Iris Synechiae
    no 57 68 42 77 13 0.0043 0.0075 0.0479 0.0421 0.3688 0.0285 0.6169 0.9506 0.3809
    Yes (100) (88) (93) (100) (93)
0 (0) 9 (12) 3 (7) 0 (0) 1 (7)
Irisatrophy
    no 55 71 43 68 12 0.3293 0.3008 0.809 0.0881 0.1171 0.4711 0.4149 0.43 ns 0.1777 0.2008 0.7839
    yes (96) (92) (96) (88) (86)
2 (4) 6 (8) 2 (4) 9 (12) 2 (14)
Iris
heterochromia 57 76 44 31 14 <0.0001 0.3878 0.258 <0.0001 0.6983 <0.0001 0.6681 <0.0001 0.5737 <0.0001
(100) (99) (98) (40) (100)
    no 1 1 46
    yes 0 (0) (1) (2) (60) 0 (0)
Vitreous haze
    no 55 69 31 30 10 <0.0001 0.1886 0.0001 <0.0001 0.0025 0.0041 <0.0001 0.0644 0.0014 0.857 0.0244
    yes (96) (90) (69) (39) (71)
2 (4) 8 (10) 8 (31) 47 (61) 4 (19)
Macular edema 54 75 40 77 13 0.0414 0.4208 0.2754 0.0417 0.7846 0.0511 0.1546 0.3809 0.0028 0.6679 0.0184
    no (95) (94) (89) (100) (93)
    yes 3 (5) 2 (6) 5 (11) 0 (0) 1 (7)
Lens
    Phakic 38 37 15 9 4 <0.0001 0.154 0.0028 <0.0001 0.008 0.884 <0.0001 0.0429 <0.0001 0.6083 0.0002
(67) (48) (33) (12) (29)
Corticonuclear cataract 11 (19) 23 (30) 14 (31) 55 (71) 3 (21)
    Posterior subcapsular 0 (0) 3 (4) 0 (0) 5 (6) 0 (0)
    cataract 8 14 16 8 7 (50)
    Pseudophakic (14) (18) (36) (10)

CMV = cytomegalovirus, GWC = Goldmann–Witmer coefficient, HSV = herpes simplex virus, IOP = Intraocular pressure, MV = multiple virus, RV = rubella virus, VZV = varicella-zoster virus

✢ not documented data excluded

Kruskal-Wallis test, Chi-square-Test, Mann-Whitney Test were performed.