Table 1.
Subset of proteins able to undergo LLPS
| Protein | MLO | Biological function | LLPS protein-protein interaction domain | Sequence motifs/structural features |
|---|---|---|---|---|
| TDP-43 | Stress granules, mRNA transport granules | RNA metabolism | 276–414 | Gly-rich polar transient α-helix (residues 320–343) |
| FUS | Stress granules, paraspeckles, DNA-damage foci, transcriptional granules | RNA metabolism | 1–163 | (S/G/X)Y(S/G/X) repeats |
| 164–267 | RG/RGG motifs | |||
| 372–422 | ||||
| 453–507 | ||||
| hnRNPA2 | Stress granules, mRNA transport granules | RNA metabolism | 190–341 | Glycine-rich RG/RGG motifs (G/X)(N/X)FG repeats |
| Elastin-like peptides | Extracellular matrix | Elastic matrix in vertebrate tissues | Hydrophobic domain | (GVPGV)7 |
| Ddx4 | Developmental granules | DEAD-box RNA helicase | 1–236 | Charge-patterning (F/R)G repeats |
| UBQLN2 | Stress granules | Proteasomal shuttle protein | 379–486 | Hydrophobic amino acids |
| Tau | Stress granules | Microtubule-binding protein | 1–441 | Charge-patterning KXGS repeats |
| FMRP | Stress granules, mRNA transport granules | RNA metabolism | 445–632 | Charge-patterning RG/RGG motifs |