Table 1.
Summary table of all calcium, β-arrestin, and p44/42 data
Calcium data are displayed as EC50 or not determined (ND) if EC50 values could not be calculated. Maximum calcium response achieved with each peptide is shown as a percentage of the maximum calcium response achievable in a given experiment revealed by calcium ionophore (% of A23187 calcium ionophore). Statistically significant shifts in EC50 values compared with PAR4-AP, AYPGKF-NH2, were found using the F-statistic (*, p < 0.05). Given that saturation did not always occur, all peptides are compared with the parental PAR4-AP, AYPGKF-NH2, and shown as a percent of the response obtained with PAR4-AP at a given concentration (100 μm). Finally, fold increase over unstimulated baseline is shown for phosphorylation of p44/42 MAPK activation. Statistical significance for comparisons at 100 μm and p44/42 phosphorylation are calculated using one-way ANOVA of response compared to PAR4-AP (*, p < 0.05).
