Table 3.
Receiver operating characteristics (ROC) curve for potential predictors of diabetes
| Parameter | AUCROC (95% CI) | Cut-off | P value of AUCROC compared with HbA1c | Sensitivity | Specificity | PPV | NPV |
| HbA1c, mmol/mol (%) | 0.90 (0.83 to 0.98) | 48 (6.5)* | – | 0.08 | 1.00 | 1.00 | 0.80 |
| UMIwake-up, mg/gCr | 0.64 (0.49 to 0.78) | 18 | <0.001 | 0.73 | 0.49 | 0.27 | 0.87 |
| UMIpremeal, mg/gCr | 0.62 (0.48 to 0.76) | 14 | <0.0001 | 0.64 | 0.40 | 0.23 | 0.80 |
| UMI2h-postprandial, mg/gCr | 0.83 (0.73 to 0.93) | 32 | 0.13 | 0.76 | 0.81 | 0.53 | 0.92 |
| ΔUMI, mg/gCr | 0.82 (0.71 to 0.93) | 7.4 | 0.18 | 0.80 | 0.80 | 0.53 | 0.94 |
ΔUMI was defined as 2-hour postprandial UMI minus premeal UMI.
*American Diabetes Association criteria for diabetes as HbA1c ≥48 mmol/mol (6.5%) was used as reference standard.
AUCROC, area under the ROC curve; NPV, negative predictive value; PPV, positive predictive value; UMI, urinary myoinositol; UMI2h-postprandial, UMI at 2-hour postprandial; UMIpremeal, UMI at premeal (fasting second urine); UMIwake-up, UMI at wake-up time (fasting first urine).