Table 2.

Pooled performance indicators for all eligible studies and subgroup analysis based on country of recruitment, mSEPT9 test cut-off level (threshold) and study sample size

	Pooled sensitivity (95% CI)	Pooled specificity (95% CI)	Pooled positive likelihood ratio (95% CI)	Pooled negative likelihood ratio (95% CI)	Pooled diagnostic OR (95% CI)
Overall	0.69 (0.62 to 0.75)	0.92 (0.89 to 0.95)	9.1 (6.1 to 13.8)	0.34 (0.27 to 0.42)	27 (15 to 48)
Country of recruitment
Asian	0.68 (0.55 to 0.79)	0.96 (0.93 to 0.97)	16 (8.9 to 28.6)	0.33 (0.22 to 0.50)	48 (19 to 126)
European	0.71 (0.58 to 0.81)	0.95 (0.92 to 0.97)	15.3 (9.3 to 25.1)	0.30 (0.20 to 0.45)	51 (25 to 104)
North American	0.68 (0.62 to 0.74)	0.85 (0.79 to 0.89)	4.4 (3.3 to 5.9)	0.38 (0.31 to 0.45)	12 (8 to 17)
Threshold level
Algorithm
1/3	0.68 (0.57 to 0.78)	0.88 (0.83 to 0.92)	5.7 (3.7 to 8.8)	0.36 (0.25 to 0.51)	16 (8 to 32)
2/3	0.69 (0.60 to 0.76)	0.95 (0.92 to 0.97)	14.6 (8.5 to 24.8)	0.33 (0.25 to 0.43)	44 (21 to 91)
Study sample size
≥100	0.71 (0.61 to 0.79)	0.93 (0.89 to 0.96)	10.4 (6.3 to 17)	0.31 (0.23 to 0.61)	33 (16 to 66)
<100	0.66 (0.57 to 0.75)	0.92 (0.85 to 0.95)	8.0 (4.2 to 15.3)	0.37 (0.27 to 0.49)	22 (9 to 52)