Table 3.
Clinical characteristics according to weight-glycemia phenotype clusters 1–6
| Characteristics, mean (SD) or n (%) |
All n=1817 |
Weight-glycemia cluster | ||||||
| Cluster 1 n=618 (34.0%) |
Cluster 2 n=195 (10.7%) |
Cluster 3 n=509 (28.0%) |
Cluster 4 n=79 (4.4%) |
Cluster 5 n=137 (7.5%) |
Cluster 6 n=279 (15.4%) |
P value† | ||
| Lipids | ||||||||
| Total cholesterol (mg/dL) | 169.6 (34.7) | 156.2 (25.7) | 154.5 (25.7) | 177.0 (31.0)** | 185.2 (37.6)** | 207.9 (51.9)** | 172.4 (29.9)** | <0.0001 |
| HDL cholesterol (mg/dL) | 55.2 (13.7) | 56.5 (13.2) | 57.2 (14.2) | 57.0 (13.8)* | 53.5 (12.6)* | 50.6 (13.3)** | 50.5 (12.3)** | <0.0001 |
| LDL cholesterol (mg/dL) | 96.1 (27.9) | 86.6 (21.5) | 83.5 (21.8)* | 100.6 (26.1)** | 104.9 (28.8)** | 120.3 (38.4)** | 103.1 (27.0)** | <0.0001 |
| VLDL cholesterol (mg/dL) | 18.2 (12.5) | 13.1 (5.0) | 13.8 (5.8) | 19.5 (10.5)** | 27.0 (16.5)** | 36.5 (25.4)** | 18.7 (9.4)** | <0.0001 |
| Triglycerides (mg/dL) | 92.3 (70.8) | 65.6 (25.0) | 68.8 (29.1) | 97.7 (52.4)** | 141.7 (123.4)** | 195.0 (152.3)** | 93.5 (47.1)** | <0.0001 |
| Blood pressure | ||||||||
| Systolic blood pressure (mm Hg) | 106.0 (10.9) | 104.9 (10.6) | 102.7 (11.2)* | 105.3 (10.1) | 104.4 (11.4) | 111.1 (9.8)** | 110.2 (11.6)** | <0.0001 |
| Diastolic blood pressure (mm Hg) | 68.5 (8.9) | 66.7 (8.5) | 66.0 (8.9) | 55.6 (23.5)** | 69.2 (9.5)* | 73.1 (8.2)** | 71.1 (32.9)** | <0.0001 |
All measures are from the cohort visit.
*Significant pairwise comparison to cluster 1, where q<0.05. **Significant pairwise comparison to cluster 1, where q<0.001. Controlled for the positive false discovery rate.
†Bonferroni-corrected p value for overall test of difference, based on use of analysis of variance (ANOVA), χ2 or Fisher’s exact test as appropriate.
HDL, high-density lipoprotein; LDL, low-density lipoprotein; VLDL, very-low-density lipoprotein.