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Hot spot residues or ligands binding sites mapped on CTLA-4 structure. Purple-shaded parts were identified as epitopes on human CTLA4. (a) Binding sites of Ipilimumab; (b) binding sites of antibody mAb146, the net indicates the N110 glycosylation site; (c) CD80 binding site (PDB code 1I8L); (d) CD86 binding site (PDB code 1I85).
