Table 2.

Univariate and multivariate Cox regression models of the 15-gene signature in predicting survival of advanced CRC.

	HR (95% CI)		HR (95% CI)
Factors	Univariate Cox analysis	P	Multivariate Cox analysis	P
TCGA training set
Risk score (high vs. low)	8.00 (4.35–14.73)	<0.001	8.19 (4.32–15.54)	<0.001
Age (≥60 vs. <60 years)	1.79 (1.08–2.98)	0.025	1.98 (1.14–3.43)	0.015
Gender (male vs. female)	0.97 (0.62–1.50)	0.879
Distal metastasis (positive vs. negative)	2.53 (1.60–4.00)	<0.001	2.61 (1.65–4.15)	<0.001
Validation set
Risk score (high vs. low)	3.85 (2.58–5.74)	<0.001	3.21 (2.14–4.84)	<0.001
Age (≥60 vs. <60 years)	1.37 (0.89–2.11)	0.152
Gender (male vs. female)	1.40 (0.95–2.05)	0.088
Distal metastasis (positive vs. negative)	4.15 (2.74–6.27)	<0.001	3.55 (2.34–5.38)	<0.001

TCGA: The Cancer Genome Atlas; CRC: colorectal cancer; HR: hazard ratio; CI: confidence interval.