Table 3. Per-Lesion Diagnostic Performance of Abbreviated MRI Sequence(s) for HCC.
| Diagnostic Criteria | Sensitivity (%)* | P† | Specificity (%)* | P† | Accuracy (%)* | P† |
|---|---|---|---|---|---|---|
| One or more findings∥ | ||||||
| T2WI | 86.8 [76.4–94.7] | 0.347‡ | 84.3 [74.7–91.4] | All > 0.990‡ | 86.0 [79.4–91.1] | All > 0.910‡ |
| DWI | 91.2 [81.8–96.7] | 0.407‡ | 88.0 [79.0–94.1] | 89.4 [83.4–93.8] | ||
| HBP | 92.7 [83.7–97.6] | 0.701‡ | 85.5 [76.1–92.3] | 88.7 [82.6–93.3] | ||
| T2WI, Dual-GRE | 89.7 [79.9–95.8] | 0.550‡ | 84.3 [74.7–91.4] | 86.8 [80.3–91.7] | ||
| DWI, Dual-GRE | 94.1 [85.6–98.4] | 0.756‡ | 86.8 [77.5–93.2] | 90.1 [84.2–94.3] | ||
| HBP, Dual-GRE | 94.1 [85.6–98.4] | 85.5 [76.1–92.3] | 89.4 [83.4–93.8] | |||
| Two or more findings | ||||||
| T2WI, HBP | 86.8 [76.4–93.8] | 0.609§ | 88.0 [79.0–94.1] | All > 0.970§ | 87.4 [81.1–92.3] | All > 0.980§ |
| DWI, HBP | 89.7 [79.9–95.8] | 0.774§ | 89.2 [80.4–94.9] | 89.4 [83.4–93.8] | ||
| T2WI, DWI | 85.3 [74.6–92.7] | 0.512§ | 90.4 [81.9–95.8] | 88.1 [81.8–92.8] | ||
| T2WI, DWI, Dual-GRE | 88.2 [78.1–94.8] | 0.744§ | 90.4 [81.9–95.8] | 89.4 [83.4–93.8] | ||
| T2WI, DWI, Dual-GRE, HBP | 91.2 [81.8–96.7] | 84.3 [74.7–91.4] | 87.4 [81.1–92.3] | |||
| Full-sequence gadoxetic acid-enhanced MRI | 92.7 [83.7–97.6] | > 0.990¶, ** | 86.8 [77.5–93.2] | > 0.990¶, ** | 89.4 [83.4–93.8] | > 0.990** |
Number in square brackets are 95% confidence intervals. *Percentage out of 151 nodules, †Bonferroni-correct p values, ‡Compared to combination of HBP and Dual-GRE, §Compared to combination of all four sequences, ∥Phrase “One or more findings” refers to presence of more than one finding among eight imaging features, known to favor diagnosis of HCC, ¶Compared to combination of T2WI, DWI, and Dual-GRE, **Compared to combination of T2WI, DWI, Dual-GRE, and HBP. Dual-GRE = dual gradient-echo in-phase and out-of-phase imaging, DWI = diffusion-weighted imaging, HBP = hepatobiliary phase imaging, T2WI = T2-weighted imaging