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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Kidney Int. 2019 Oct 22;97(3):528–537. doi: 10.1016/j.kint.2019.09.025

Figure 5. Mean steady-state relative mRNA levels of pro-inflammatory and fibrotic molecules were increased in kidney microvasculature of HT SS, but not SSEts1+/−, rats.

Figure 5

A, Kidney microvascular mRNA expression of inflammatory mediators, VCAM, ICAM and P-selectin increased 1.6-, 1.9- and 3.7-fold, respectively, in HT SS rats and were significantly higher than levels observed in the microvessels of Pre-HT SS, Pre-HT SSEts1+/−, and HT SSEts1+/− rats. *p-value < 0.05 versus Pre-HT SS, Pre-HT SSEts1+/−, and HT SSEts1+/− groups; n=6 animals in each group. B, Kidney microvascular mRNA expression of fibrotic molecules, TGF-β, collagen I and osteopontin increased 1.5-, 1.6- and 2.3-fold, respectively, in HT SS rats and were greater than corresponding levels in microvessels of Pre-HT SS, Pre-HT SSEts1+/−, and HT SSEts1+/− rats. *p-value < 0.05 versus Pre-HT SS, Pre-HT SSEts1+/−, and HT SSEts1+/− groups; n=6 animals in each group.