Mean spontaneous withdrawal scores (+SEM) at 1, 2, 4, 6 & 24 hours post-nicotine exposure following the 10th day of nicotine e-vape exposure for the 20, 40 and 80 mg/mL nicotine concentration groups (N=6/group). * p≤0.05, ** p≤0.01 and *** p≤0.001 compared with baseline; # p≤0.05 compared with 1 and 2 hours post-nicotine; $ p≤0.05 and $$ p≤0.01 compared with the 20 mg/mL nicotine concentration group; †† p≤0.01 and ††† p≤0.001 compared with the 80 mg/mL nicotine concentration group. Significance symbols are reported over and under the corresponding dataset.