Mean precipitated withdrawal scores (+SEM) at 1, 2, 4, 6, 24 & 48 hours post-nicotine exposure on the 11th day of nicotine e-vape exposure for the 20, 40 and 80 mg/mL nicotine concentration groups (N=6/group); * p≤0.05, ** p≤0.01 and *** p≤0.001 compared with baseline; # p≤0.05, # # p≤0.01 and # # # p≤0.001 compared with the 20 mg/mL nicotine concentration group; $ p≤0.05 compared with the 40 mg/mL nicotine concentration group. Significance symbols are reported over, beside and under the corresponding dataset.