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. 2019 Nov 26;13(2):322–333. doi: 10.1038/s41385-019-0235-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Levels of S100A8 (calprotectin) in faeces from uninfected and infected mice (8 dpi: C57-closed circles; 6 dpi: C3H-closed squares) as determined by ELISA. Multiple comparison one-way ANOVA, n.s. = non-significant, *P ≤ 0.05, ***P ≤ 0.001. b The number of Ly6G-positive cells were counted per colonic section from individual mice (n = 8–9). Multiple comparison one-way ANOVA, n.s. = non-significant, *P ≤ 0.05, **P ≤ 0.01. Representative images shown Fig. S2. c Measurements of faecal NE activity in uninfected and infected (C57, 8 dpi-closed circles; C3H, 6 dpi-closed squares) mice, measured using a fluorogenic tetrapeptide substrate. Purified recombinant NE was used as a control (diamond). Grey squares indicate samples treated with Sivelestat. Multiple comparison one-way ANOVA, ***P ≤ 0.001. d Faecal S100A8 ELISA (calprotectin) of samples taken from C57 mice pre-treatment (0) and at 8 days post treatment (1.5% DSS- closed circles; 3% DSS- closed squares). Multiple comparison one-way ANOVA, n.s. = non-significant, **P ≤ 0.01. e Faecal NE activity in samples from C57 mice pre-treatment (0) and at 8 days post treatment (1.5% DSS- closed circles; 3% DSS- closed squares). Purified rNE was used as a control (diamond). Grey squares indicate samples treated with Sivelestat. Multiple comparison one-way ANOVA, *P ≤ 0.05.