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. 2019 Nov 26;13(2):322–333. doi: 10.1038/s41385-019-0235-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Mann–Whitney test of rate of cleavage of NE substrate in IBD samples from ulcerative colitis (UC) patients classified as having inactive (circles, n = 13) and active (squares, n = 14) disease, ***P ≤ 0.001. b Receiver operating characteristic (ROC) curve analysis of accuracy of NE activity and faecal calprotectin to predict active and inactive disease. Area under curve (AUC) for NE activity = 0.8681 and 0.8462 for calprotectin.