Table 3.

Univariate and multivariate analyses of prognostic factors for overall survival and recurrence-free survival

Variables	Overall survival			Recurrence-free survival
	Univariate	Multivariate		Univariate	Multivariate
	P value	HR (95%CI)	P value	P value	HR (95%CI)	P value
Sex (M/F)	0.595			0.962
Age (> 50/< 50 yr)	0.020	1.853 (1.243-2.761)	0.002	0.071
BMI (≥ 24/<24 kg/m2)	0.596			0.770
Cause of hepatitis (HBV/HCV/others)	0.269			0.422
ALT (> 40/≤ 40 U/L)	0.255			0.069
AFP (≥ 400/< 400 μg/L)	0.111			0.092
INR (≥ 1.3/< 1.3)	< 0.001			0.009
PLT (≥ 100/< 100 × 109/L)	0.392			0.713
Number of tumors (single/≥ 2)	0.243			0.065
Tumor size (≥ 5/< 5 cm)	< 0.001			< 0.001
Blood transfusion (yes/no)	0.001			0.003
Surgical bleeding (> 400/≤ 400 mL)	0.005			0.003	1.437 (1.004-2.058)	0.048
Types of liver resection (minor/major)	< 0.001			< 0.001
Intraoperative radiotherapy and/or chemotherapy (yes/no)	0.649			0.430
PVTT (yes/no)	< 0.001			0.005
Capsule formation (yes/no)	0.408			0.374
Differentiation (good/poor)	0.004	2.230 (1.452-3.426)	< 0.001	0.029
PH (yes/no)	0.809			0.542
Liver cirrhosis (yes/no)	0.944			0.896
Child-Pugh grade (A/B)	< 0.001			0.001
BCLC stage (0 or A/B/C)	< 0.001			< 0.001
0 or A		1			1
B		2.635 (1.235-5.622)	0.012		2.246 (1.095-4.607)	0.027
ALBI grade (1/2/3)	< 0.001			0.003
MCP grade	< 0.001			< 0.001
1		1			1
2		1.864 (1.174-2.959)	0.008		1.830 (1.246-2.687)	0.002
3		2.005 (1.071-3.753)	0.030

BMI: Body mass index; PH: Portal hypertension; C-P: Child-Pugh; BCLC: Barcelona Clinic Liver Cancer; PVTT: Portal vein tumor thrombus; ALBI: Albumin-Bilirubin; MCP: Modified Child-Pugh. Type of liver resection: Minor, ≤ 3 liver segments; major, ≥ 4 liver segments. Intraoperative radiotherapy: Implanted with radiation particles I¹²⁵ or I¹³¹. Intraoperative chemotherapy: Implanted with a chemotherapy pump.