Table 3.
Univariate and multivariate analyses of prognostic factors for overall survival and recurrence-free survival
| Variables |
Overall survival |
Recurrence-free survival |
||||
|
Univariate |
Multivariate |
Univariate |
Multivariate |
|||
| P value | HR (95%CI) | P value | P value | HR (95%CI) | P value | |
| Sex (M/F) | 0.595 | 0.962 | ||||
| Age (> 50/< 50 yr) | 0.020 | 1.853 (1.243-2.761) | 0.002 | 0.071 | ||
| BMI (≥ 24/<24 kg/m2) | 0.596 | 0.770 | ||||
| Cause of hepatitis (HBV/HCV/others) | 0.269 | 0.422 | ||||
| ALT (> 40/≤ 40 U/L) | 0.255 | 0.069 | ||||
| AFP (≥ 400/< 400 μg/L) | 0.111 | 0.092 | ||||
| INR (≥ 1.3/< 1.3) | < 0.001 | 0.009 | ||||
| PLT (≥ 100/< 100 × 109/L) | 0.392 | 0.713 | ||||
| Number of tumors (single/≥ 2) | 0.243 | 0.065 | ||||
| Tumor size (≥ 5/< 5 cm) | < 0.001 | < 0.001 | ||||
| Blood transfusion (yes/no) | 0.001 | 0.003 | ||||
| Surgical bleeding (> 400/≤ 400 mL) | 0.005 | 0.003 | 1.437 (1.004-2.058) | 0.048 | ||
| Types of liver resection (minor/major) | < 0.001 | < 0.001 | ||||
| Intraoperative radiotherapy and/or chemotherapy (yes/no) | 0.649 | 0.430 | ||||
| PVTT (yes/no) | < 0.001 | 0.005 | ||||
| Capsule formation (yes/no) | 0.408 | 0.374 | ||||
| Differentiation (good/poor) | 0.004 | 2.230 (1.452-3.426) | < 0.001 | 0.029 | ||
| PH (yes/no) | 0.809 | 0.542 | ||||
| Liver cirrhosis (yes/no) | 0.944 | 0.896 | ||||
| Child-Pugh grade (A/B) | < 0.001 | 0.001 | ||||
| BCLC stage (0 or A/B/C) | < 0.001 | < 0.001 | ||||
| 0 or A | 1 | 1 | ||||
| B | 2.635 (1.235-5.622) | 0.012 | 2.246 (1.095-4.607) | 0.027 | ||
| ALBI grade (1/2/3) | < 0.001 | 0.003 | ||||
| MCP grade | < 0.001 | < 0.001 | ||||
| 1 | 1 | 1 | ||||
| 2 | 1.864 (1.174-2.959) | 0.008 | 1.830 (1.246-2.687) | 0.002 | ||
| 3 | 2.005 (1.071-3.753) | 0.030 | ||||
BMI: Body mass index; PH: Portal hypertension; C-P: Child-Pugh; BCLC: Barcelona Clinic Liver Cancer; PVTT: Portal vein tumor thrombus; ALBI: Albumin-Bilirubin; MCP: Modified Child-Pugh. Type of liver resection: Minor, ≤ 3 liver segments; major, ≥ 4 liver segments. Intraoperative radiotherapy: Implanted with radiation particles I125 or I131. Intraoperative chemotherapy: Implanted with a chemotherapy pump.