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. 2020 Feb 24;11(2):149. doi: 10.1038/s41419-020-2335-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Pimozide structure. b KHOS/NP, MG63, and SJSA-1 cells were incubated with increasing doses of pimozide (0–40 μM), and cell proliferation was determined. Pimozide treatment resulted in a significant dose-and time-dependent decrease in cell proliferation in all cell lines when compared with controls. c KHOS/NP, MG63, and SJSA-1 cells were incubated with 10 µM pimozide for 48 h and the cells were allowed to grow and form colonies. Pimozide treatment inhibits colony formation. Results are representative of three independent experiments. d and e Pimozide at 20 μM concentration specifically inhibits the growth of KHOS/NP GFP positive cells, but not the normal cells in the TiD system. Scale bars represent 100 μm.