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. 2020 Feb 24;10:3304. doi: 10.1038/s41598-020-59256-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genetic correlations between HIV-1 acquisition susceptibility and traits tested within the UK Biobank. (A) Correlations performed within LD Hub using the LDSC model to determine genetic correlations between HIV-1 acquisition and 516 heritable traits. The Bonferroni-significant correlations (rg) are displayed in red and delimited by the horizontal line (P = 0.05/516 traits = 8.38 × 10⁻⁵). (B) Validation of the Bonferroni-significant findings using SumHer-GC, which is based on the LDAK model, adjusting for genomic control. The correlation values observed for the 14 Bonferroni-significant traits associated with HIV-1 acquisition in the LDSC method were highly concordant with results using the LDAK method (Pearson’s r = 0.98, P = 2.59 × 10⁻⁹).