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. 2020 Feb 24;10:3231. doi: 10.1038/s41598-020-59842-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo MRI with an albumin-binding probe and ex vivo assessment in sham animals. (A1) 3D visualization showing the suprarenal abdominal aorta (AA) with the renal arteries (rA) of a male ApoE^−/− mouse after 4 weeks of saline infusion. The green line indicates the orientation of subsequently acquired transverse MRI sequences and the corresponding histological sections. (A2) Time-of-flight angiography of the AA. (A3) Delayed-enhancement imaging after administration of the albumin-binding probe gadofosveset. Fusion A2/A3 shows a fusion of images A2 and A3 for better visualization of in vivo results. A4-A7 are images of ex vivo histology. A4 and its corresponding magnification A5 show an albumin-specific staining with only minor immunopositive fluorescent areas of albumin. A6 corresponds to a Hematoxylin and Eosin (H&E) staining of the aortic tissue and A7 shows an Elastica van Gieson (EvG) staining of elastic fibers. In summary, we see, that no pathological changes of the aortic wall can be observed in vivo based on delayed-enhancement imaging with the albumin-binding probe gadofosveset (A3, A2/A3) or on corresponding ex vivo histology (A4-7). Abbreviations: H&E: Hematoxylin and Eosin staining; EvG: Elastica van Gieson staining of elastic fibers; TOF-MRA: time-of-flight magnetic resonance angiography; AA: suprarenal abdominal aorta; RA: right renal artery; gadofosveset: albumin-binding probe. +: vascular lumen in arterial TOF.