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. 2020 Feb 24;11:1017. doi: 10.1038/s41467-020-14813-z

Fig. 1. PV-Lmo4KO mice display autism-like behaviors.

Fig. 1

a KO mice have reduced social interaction. The sociability discriminative index compares the time spent in the interaction zone when a littermate is present or absent. The novelty index compares the interaction with a “stranger” to the interaction with a familiar littermate. n = 8 WT, 14 KO mice. b KO mice show increased self-grooming (n = 7 WT, 10 KO) and c digging compared to littermate controls (n = 8 WT, 11 KO). d c-Fos staining revealed neuronal activation in L2/3 of ACC in mice 30 min after social interaction. NSI, no social interaction; SI, social interaction. c-Fos+ neuron numbers were counted and normalized to WT NSI. * and **** are SI compared to NSI for each genotype. n = 4 mice per genotype per condition. Scale bar, 50 μm. All data are presented as means ± SEM. *, **, ##, ****, p < 0.05, 0.01, 0.01, 0.0001, respectively.