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. 2020 Feb 24;10:3229. doi: 10.1038/s41598-020-60213-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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T2DM impaired the fold-change and differential avidity index of IgG. (a) The avidity index of influenza-specific IgG antibody at several time points or (b) differential avidity index of an influenza-specific IgG antibody response compared with baseline and D30 or D90 or D270 post-vaccination in all individuals. Statistical analyses were undertaken using two-way ANOVA. Horizontal lines represent (a) the mean with 95% CI or (b) the median with interquartile range. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.