Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 24;10:3229. doi: 10.1038/s41598-020-60213-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Metformin (but not glibenclamide) reduced IFN-α expression in human monocytes after seasonal vaccination. Monocytes from individuals without DM (non-DM; n = 5) were treated with metformin (Met) or glibenclamide (GB) or a combination of both for 30 min. Drug-treated monocytes were incubated with poly I:C or TIV (influenza split-virion) for 3 h before RNA extraction and determination of IFN-α expression by real-time PCR. Expression is shown as fold expression. Each point represents an individual. Statistical analyses were undertaken using one-way ANOVA. Horizontal lines represent the median with interquartile range. ****p < 0.0001; ns, not significant.