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. 2020 Feb 24;11(2):145. doi: 10.1038/s41419-020-2336-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Heat map showed the upregulated circRNAs and downregulated circRNAs. b Sanger sequencing illustrated the joint site of circRNF20 (3’-end of exon 5 and 5’-end of exon 3). c Schematic diagram illustrated the formation of circRNF20 originated from RNF20 pre-mRNA (exon 3, 4, 5). d RT-PCR revealed the expression of circRNF20 in the BC cell lines. e RNA stability assay found the expression of circRNF20 or linear mRNA transcript in MDA-MB-231 cells under treatment with transcription inhibitor (actinomycin D). f RT-PCR showed the expression of circRNF20 and RNF20 mRNA in MDA-MB-231 cells administered with RNase R or Mock control. g RT-PCR showed the circRNF20 level in the BC tissue. h Prognosis analysis calculated by Kaplan-Meier and log-rank test unveiled the survival rate of BC patients with higher or lower circRNF20 expression. **p < 0.01 vs. control.