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. 2020 Feb 24;10:3247. doi: 10.1038/s41598-020-60070-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Standard curve of ELISA human pulp fibroblast cytokines IL-6, (b) Standard curves of ELISA human pulp fibroblast cytokines IL-8, (c) ELISA measurement of cytokines IL-6 levels, (d) ELISA measurement of cytokines IL-8 levels. *Indicates a significant difference of cytokines IL-6 and IL-8 levels of the bare NiTi, GO-coated NiTi (GO), and GO/Ag-coated NiTi (GOAg) alloy compared to the control (P < 0.001).