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. 2020 Feb 24;10:3272. doi: 10.1038/s41598-020-60127-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic overview of differential interactome analysis between two phenotypes. (A) Highly probable protein-protein interactions (PPIs) in each phenotype. (B) Comparative analysis of interactome profiles of the phenotypes leads to the identification of differential PPIs, which are categorized into two groups as repressed or activated under the phenotype of interest (e.g., diseased phenotype). (C) Differentially interacting proteins (DIPs) representing significant changes in their interaction patterns during the transition between the phenotypes.