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. 2020 Feb 24;10:3272. doi: 10.1038/s41598-020-60127-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential interactome in human cancers. (a) Bar chart showing the numbers of interactions being specific and non-specific to the cancer types and their count ratio in the 12 different cancer types. (b) Graph indicates the prevalence of dPPIs in different cancers. (c) Topological characteristics of differential interactome networks. Bean plots represent the distribution of topological metrics (i.e., clustering coefficient, network diameter, network centralization, characteristic path length, average number of neighbors, network heterogeneity, number of nodes, and number of interactions) across constructed differential interactome networks. The individual observations are shown as small lines.