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. 2020 Feb 24;10:3341. doi: 10.1038/s41598-020-60133-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Experimental workflow for miRNA-seq analysis of rat hippocampus after fluid percussion injury (FPI). (B) Principal component analysis (PCA) revealed miRNAs capable of discriminating between TBI and sham-injured controls at 24 h to 1 y post FPI. (C) Analysis of miRNA-seq data in EdgeR and DESeq2 (using both the Wald test and LRT [Likelihood-ratio test] in each) identified four miRNAs that were significantly different compared to sham injured controls in at least one post-injury interval. The *denotes significant [FDR < 0.05] differential expression in both Wald and LRT tests and #denotes significant [FDR < 0.05] differential expression per Wald or LRT test. (D) Differentially expressed rat serum miRNAs that are significant compared to sham-injured rats by PCR array analysis after FPI or CCI. Data are displayed graphically as the log2 ratio ± SEM along the y-axis and miRNAs are listed along the x-axis. Data were analyzed through the use of IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuitypathway-analysis) and Qlucore Omics Explorer.