Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 24;10:3341. doi: 10.1038/s41598-020-60133-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

(A) Experimental workflow for miRNA-seq and bioinformatic analysis of human uninjured control and TBI patient samples. (B) The top 10 up- and down-regulated miRNAs by level of significance (FDR adjusted p-value) in the 24 hr patient cohort. Ingenuity Pathway Analysis of predicted gene targets show the top nervous system-related canonical pathways for the up and down miRNAs, respectively are involved in synaptic plasticity, neurorestorative signaling and neuroinflammation. The x-axes are based on the -log of the Fisher’s Exact p-value. (C) Consistent expression of miRNAs across three acute periods after TBI. Data is displayed graphically as the log2 ratio ± SEM (y-axis) and significant miRNAs from the LRT and Wald tests in EdgeR and DESeq2 (x-axis). Red bars indicate 24 hrs, green 48 hrs, and blue 96 hrs after TBI. SEM – standard error of the mean; LRT – likelihood ratio test; hsa – human miRNA. Data were analyzed through the use of IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuitypathway-analysis).