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. 2020 Feb 24;10:3341. doi: 10.1038/s41598-020-60133-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pathway analysis reveals predicted gene targets enriched in predominately nervous system signaling pathways for focal (A) or diffuse (B) injury cohorts. miRNA colors signify increased (red) expression compared to control samples. The color of the gene targets represents the predicted direction of regulation based on target-prediction using miRDB. The green circles represent biological pathways comprising of predicted genes based on Ingenuity Pathway Analysis. Data were analyzed through the use of IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuitypathway-analysis).